Products

 Pravastatin Sodium
 Mevastatin/Compactin
 Mycophenolic Acid

Contact: Mr. Kang / Ms. Lin
TEL:  0086-763-3865280
 0086-763-3865278
FAX:  0086-763-3366526
ADD:  Renmin One Road 
 Qingyuan Guangdong
 China
P.C.:  511515

 

 

 

 

Products of APIs

Common Name:Pravastatin Sodium

QUALITY STANDARD:Compliant with USP, EP and JP

CAS Registry Number:81131-70-6

Molecular Formula:C23H35NaO7

Molecular Mass:446.52



Structural Formula

Chemical  Name:(1S-(1-alpha(beta-S*,delta-S*)-2-alpha,6-alpha,8-beta(R*),8a-alpha))-1,2,6,7,8,8a-hexahydro-2-methyl-8-(2-methyl-1-oxobutoxy)-beta,delta,6-trihydroxy-1-Naphthaleneheptanoic acid monosodium salt
                   
Appearance: White  or off-white crystalline powder
 
Therapeutic Category:Antihyperlipidemic; inhibitor (HMG - CoA reductase)
 
Mechanism of action: HMG-CoA  reductase is the rate-limiting enzyme for cholesterol synthesis. Pravastatin  inhibits cholesterol synthesis by reversibly inhibiting HMG-CoA reductase.  Pravastatin functions in two aspects: (1) reduces cellular cholesterol  synthesis by reversibly inhibiting HMG-CoA reductase activity, so as to  increase low density lipoprotein (LDL) receptors, (2) inhibits the prodrug of  LDL-- very low density lipoprotein (VLDL) in liver so as to inhibit the  synthesis of LDL.
                 
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