Products of APIs
Common Name:Pravastatin Sodium
QUALITY STANDARD:Compliant with USP, EP and JP
CAS Registry Number:81131-70-6
Molecular Formula:C23H35NaO7
Molecular Mass:446.52

Structural Formula
Chemical Name:(1S-(1-alpha(beta-S*,delta-S*)-2-alpha,6-alpha,8-beta(R*),8a-alpha))-1,2,6,7,8,8a-hexahydro-2-methyl-8-(2-methyl-1-oxobutoxy)-beta,delta,6-trihydroxy-1-Naphthaleneheptanoic acid monosodium salt
Appearance: White or off-white crystalline powder
Therapeutic Category:Antihyperlipidemic; inhibitor (HMG - CoA reductase)
Mechanism of action: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis. Pravastatin inhibits cholesterol synthesis by reversibly inhibiting HMG-CoA reductase. Pravastatin functions in two aspects: (1) reduces cellular cholesterol synthesis by reversibly inhibiting HMG-CoA reductase activity, so as to increase low density lipoprotein (LDL) receptors, (2) inhibits the prodrug of LDL-- very low density lipoprotein (VLDL) in liver so as to inhibit the synthesis of LDL.
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